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Patients using oral contraceptives should use a non-oral or backup contraceptive method for 4 weeks after initiating Zepbound and for 4 weeks after each dose increase, as the medication may delay gastric emptying and affect absorption of oral medications

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Severe allergic reactions including Stevens-Johnson syndrome affect less than 1% of users but can be fatal, typically appearing as widespread skin blistering within 1-3 weeks of starting treatment

Unlike peptide, the binding of compound 2 and other small molecule modulators require a complementary conformation of the ECD for ligand recognition, such that the N-terminal -helix of the compound 2GLP-1RG s deeply inserted to the orthosteric binding pocket as opposed to other GLP-1R structures (Fig