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of 28 studies involv- ing 304,060 individuals with 481 documented aspiration cases found that GLP-1 RA exposure was not associated with increased pulmonary aspiration (odds ratio 1.04, 95% condence interval 0.871.25) despite a signicant asso- ciation with retained gastric contents (odds ratio 5.96, 95% condence interval 3.968.98) [38]

The first approach involves creating GLP-1 receptor agonist peptides (also known as GLP-1 mimetics), which are not easily broken down by DPP-IV due to their low affinity for this enzyme, thus providing a longer circulation time

2.2.1 Background PD is the second-most common neurodegenerative disorder after AD

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For most patients, the constipation is worst during the first 3 months of treatment or during dosage increases (e.g., moving from 5mg to 7.5mg )