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GLP-1-Based Strategies for the Treatment of T2DM A GLP-1-based strategy for the treatment of T2DM is indicated in view of the fact that GLP-1R agonists and DPP-IV inhibitors exert a beneficial constellation of physiological effects that include (1) glucose-dependent stimulation of insulin secretion, (2) suppression of glucagon secretion, (3) normalization of blood glucose without an attendant risk of hypoglycemia, (4) slowing of gastric emptying, (5) appetite suppression, and (6) weight loss