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In patients with diabetes and a history of peripheral vascular events, GLP-1 therapies were associated with reduced risk of amputation, major adverse cardiovascular events, cardiovascular death, all-cause mortality, and progression to dialysis compared with other glucose-lowering medications (Hsiao et al., 2026)

Patients with pre-existing cardiac conditions , particularly those with heart failure or significant arrhythmias, should be monitored appropriately when initiating GLP-1 receptor agonist therapy

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