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A report examining PMI data on Sprague Dawley rats exposed to IQOS smoke or CS for 90 days observed increased markers of acute hepatotoxicity, including liver weight and alanine aminotransferase, in the IQOS-exposed group 54

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These products are produced legally in low-tax jurisdictions, but often intended for smuggling.[12] Reports from this year indicate that the Chinese tobacco monopoly is playing a significant role in the illicit whites tobacco markets in Central and South America

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