In parallel, 336 KOs were found to be inversely proportional to the BWG, including those encoding for bacterial biosynthesis of cofactors and amino acids (e.g., phenylalanine, tyrosine, tryptophan, histidine, and lysine), carbon and pyruvate metabolism (including glycolysis/gluconeogenesis, galactose metabolism, and carbon fixation), together with the metabolism of nucleotides (including DNA replication and homologous recombination) and the metabolism of starch and sucrose and fructose and mannose
Using a collagen gel contraction assay, we observed that primary fibroblasts from the lungs of aged GHK-treated mice exhibited enhanced contraction compared to fibroblasts from placebo-treated mice (Figure 4), further supporting the hypothesis that GHK promotes the resolution of collagen scars
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