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Methods A comprehensive literature search of English articles published up to June 2023 was conducted using PubMed and Scopus databases
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Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease
Pancreatic cancer risk in patients treated with GLP-1 receptor agonists: a 9-year nationwide cohort study
Chronic metabolic conditions are characterized by: Increased production of reactive oxygen species Impaired antioxidant defenses Mitochondrial dysfunction Chronic inflammation Cellular damage to pancreatic -cells, adipocytes, and hepatocytes How GLP-1 Affects Oxidative Stress Research has revealed that GLP-1 receptor agonists exert antioxidant effects through several mechanisms: Direct antioxidant signaling: Activation of the GLP-1 receptor triggers cellular pathways that reduce ROS production Anti-inflammatory effects: Decreases production of pro-inflammatory cytokines that contribute to oxidative stress Mitochondrial protection: Improves mitochondrial function and reduces oxidative damage Endothelial function: Enhances nitric oxide production and vascular health However, during weight loss especially rapid weight loss induced by GLP-1 RAs patients may experience increased oxidative stress due to the mobilization of stored toxins from adipose tissue
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