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Cells with impaired PERK-eIF2a-ATF4 signal transduction are more sensitive to hypoxic stress in vitro , indicating that the PERK-eIF2a-ATF4 pathway provides a survival advantage for cells under hypoxic conditions (75, 76), which is crucial for resistance to intracellular hypoxia, metabolic stress, and starvation

More than three-quarters of ischemic optic neuropathy cases are classified as non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition that typically causes sudden blurring, dimming or loss of part of the visual field in one eye

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