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This is hugely promising because it suggests that, in the future, medications like tirzepatide could not just manage but potentially prevent type 2 diabetes something weve never had a reliable way to do before at scale

(2) Alzheimer's disease (progressive synapse and neuron loss)

Neither semaglutide nor tirzepatide significantly increased hepatic or pancreatic adverse events in their respective trial programs

Thus, we hypothesized that the elevated non-12-OH FXR-antagonistic BA levels contribute to the glucose-lowering effect of T3 through the regulation of GLP-1 and insulin production via inhibiting intestinal FXR signaling