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p53 ablation in adipocytes de-represses catabolic and oxidative gene expression As we observed exacerbated weight loss, increased plasma NEFAs, and heightened lipolysis in explants in the HFD-IF-KO group (Fig

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Challenges and perspectives Clinical translation In recent years, engineered bacteria have emerged as a promising platform technology for treating liver diseases due to their ability to passively distribute in liver tissues, modulate immune responses, and alleviate metabolic abnormalities

Until such studies are conducted, the combination remains investigational and should be approached with appropriate caution, written informed consent, and consideration of FDA MedWatch reporting for any adverse events that occur with off-label combination use