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CRP levels in OA patients included in this study were all within the normal range

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

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Kent KD, Harper WJ, Bomser JA

They do this by mimicking a hormone called glucagon-like peptide 1, or GLP-1