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Recycling of BH 4 requires dihydrofolate reductase (DHFR), and if DHFR is inhibited, then BH 4 cooperates with GPX4 to induce ferroptosis [48]

Protect from light and check the leaflet for the allowable time at room temperature if refrigeration isnt possible for a short period

The MHRA's framework for supplying unlicensed medicinal products ('Specials') and named-patient import routes exist for certain unlicensed medicines, but these mechanisms are generally not applicable to investigational products that are not yet commercially available

Rubin, A

2024 ESC Guidelines for the management of peripheral arterial and aortic diseases