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The SURMOUNT-5 trial showed that tirzepatide produced 20.2% body weight reduction compared to 13.7% with semaglutide over 72 weeks, a significant gap that suggests tirzepatide may push past the metabolic ceiling where semaglutide stalls

There is an increase in cost if you choose to move to the high-dose protocol

These powerful effects can also change how your body processes fluids : Slower gastric emptying means water and food stay in your stomach longer

It is not licensed or approved as a medicine for human use in the UK or elsewhere

Pfizer's monthly dosing candidate shows real potential, while Boehringer's entry disappointed on weight loss metrics despite liver fat benefits