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S2 = standard deviation of the studied result (SD)
Accumulating evidence has established butyrate as a key epigenetic regulator of ubiquitin signaling networks, particularly influencing protein homeostasis in cellular antioxidant systems and ferroptosis pathways
Drug resistance mechanisms beyond DPP9-NRF2 (255) and AIM2-FOXO3a (258) are also underexploredwhether epigenetic modifications (e.g., DNA methylation of ACSL4), post-translational regulation (e.g., GPX4 ubiquitination), or metabolic rewiring (e.g., alternative antioxidant pathways) drives acquired resistance to ferroptosis inducers requires investigation
24 KulkarniR.AcharyaJ.GhaskadbiS.GoelP
PMID: 34406872
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