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Over time, the brains cooling system wears down, leading to agitation, poor sleep, and cognitive fatigue

Ditano-Vzquez P, Torres-Pea JD, Galeano-Valle F, Prez-Caballero AI, Demelo-Rodrguez P, Lopez-Miranda J et al (2019) The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil

It works by breaking down histamine that has been produced inside cells by the HDC enzyme.3 Heres a look at some of the key enzymes involved in Histamine Metabolism:4 HNMT requires SAM as a cofactor

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