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In SURMOUNT-1, participants on 5 mg lost an average of 15% body weight over 72 weeks

doi: 10.1038/s41419020-033624 58 BelavgeniAMeyerCStumpfJHugoCLinkermannA

Ideal for pre-competition protocol: from 10 days before to the day of competition

Importantly, bi-functionalization significantly enhances BBB permeability in vitro and in vivo by up to five-fold compared to mono-functionalized liposomes because of the optimized size ( 2x) and 46% release at pH 5.5, facilitating cytosolic delivery, while being stable at pH 7.4