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Within one year of stopping, they regained two-thirds of the weight they had lost

Furthermore, several clinical trials are currently recruiting to look at how GLP-1R agonists might affect the progression of prostate and endometrial cancers

While rare, individuals may encounter more severe side effects such as gallbladder complications, kidney issues, or an elevated risk of low blood sugar (hypoglycemia) when combined with other diabetes medications

Summary: GLP-1 receptor agonists are not formally associated with leg cramps, but indirect mechanisms such as dehydration and electrolyte imbalances from gastrointestinal side effects may contribute to muscle cramping in some patients

Regulation of renal function by the gastrointestinal tract: potential role of gut-derived peptides and hormones