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As a result, the fiber cant assemble the latticework for the gel in the duodenum, so its not protecting the liver from the onslaught of the sugar in the fruit smoothie. If you just ate the whole fruit as is, he said, the insoluble fiber would combine with the soluble fiber to form a gel that reduces the rate of absorption of sugars and slows the breakdown of starches

Cersosimo E, Triplitt C, Solis-Herrera C, Mandarino LJ, DeFronzo RA

PMID: 36977934 3 GLP-1 receptor agonists and delayed gastric emptying: implications for invasive cardiac interventions and surgery

Opava-Komarov, Czech Republic Manufactured For: TEVA PHARMACEUTICALS USA Sellersville, PA 18960 Rev

This interpretation is supported by the observations that GLP-1 injected locally into the arcuate nucleus reduces hepatic glucose production but does not affect food intake (20), whereas injection into the paraventricular nucleus of the hypothalamus suppresses food intake