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Studies show that GLP-1 agonists preferentially reduce visceral (deep belly) fat before subcutaneous fat (the layer under your skin), which is metabolically favorable because visceral fat is linked to insulin resistance, type 2 diabetes, and cardiovascular disease

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It reduces brain edema, hemorrhagic lacerations, and subarachnoid bleeding in TBI models

Evidence on muscle strength is mixed: some short-term studies show preserved handgrip or leg strength despite reduced muscle size (possibly due to loss of non-contractile tissue), while longer-term data and animal models suggest potential weakening even with modest mass changes