FOXO4 is a forkhead box O transcription factor that mediates various signaling pathways to maintain cellular homeostasis 33
Research applications include studying how senescent immune cells affect vaccine efficacy, immune surveillance, and infection resistance in aging models, providing insights into interventions for age-related immune decline and immunosenescence mechanisms
Whilst fatty liver disease itself may not directly cause B12 deficiency, the constellation of metabolic conditions, medications, and lifestyle factors commonly associated with fatty liver can collectively increase vulnerability to deficiency
Acute Kidney Injury: In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse
We see this in human HCM myocardium (reduced CK protein and activity) and across several models that pin down causality