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Normally, the body's antioxidant defenses, led by glutathione, neutralize these ROS seamlessly

doi: 10.1161/HYPERTENSIONAHA.107.097386 12 AtefiN.BehrangiE.MozafarpoorS.SeirafianpourF.PeighambariS.GoodarziA

By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models

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