In Drosophila melanogaster , reducing 3- O sulfation causes Notch-associated neurogenic phenotypes and lower levels of Notch protein 56
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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA- c) is a small peptide comprised of 16 amino acids, which is encoded by DNA not in the nucleus, but inside the mitochondrial genome, specifically inside the gene that encodes the mitochondrial 12S ribosomal RNA
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