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Clinical trials lasting 68 weeks showed that participants on semaglutide maintained significant weight loss throughout the treatment period, with continued improvements in metabolic markers including blood sugar, blood pressure, and cholesterol levels

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It adds that clinical data on the strategy is still emerging

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Tirzepatide vs Semaglutide for Metabolic Research: What the Head-to-Head Evidence Shows The most definitive head-to-head data comes from SURMOUNT-5, published in the New England Journal of Medicine in 2025