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Pre-autonomic neurons are located in the PVN 24 and are partly controlled by inhibitory GABA projections from the lateral hypothalamus (LH) acting on PVN GABA A receptors (GABA A R) 25,26,27

doi: 10.1002/hed.25356 37 AdamMAPuraJGuLDinanMATylerDSReedSDet al

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Starting dose also dramatically affects symptom intensity and timelinepatients beginning at lower microdoses experience gentler side effects over a longer onset period, while standard-dose starts typically produce more noticeable symptoms faster