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Instead, they act as ATP-independent holdases that bind misfolded or partially unfolded proteins, preventing their aberrant aggregation and facilitating subsequent degradation

Additionally, the potential of combining treatment modalities and some emerging drugs are highlighted

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Understanding how these side effects may indirectly contribute to other conditions, such as hemorrhoids, is important for comprehensive patient care and counseling

Oral bioavailability for a bare tripeptide is expected to be very low due to GI enzymatic degradation, though the sublingual route bypasses first-pass hepatic metabolism