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Chest 128 , 16111619 (2005)

Before beginning glutathione IV therapy, consider these key points: Consult with a qualified healthcare provider to determine if youre a good candidate

-glutamyl kinase (GK) encoded by PRO1 in eukaryotes or proB in prokaryotes, the first enzyme in proline biosynthetic pathway, catalyzes the formation of intermediate -glutamyl phosphate, which if accumulated could partially react with cysteine to generate -GC, and then Gsh2 adds glycine to -GC to form GSH

Nevertheless, clinical translation remains hindered by several unresolved limitations

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