4.2 Detailed expandable studies Here are the 7 most important studies that researchers in this field reference most often
B12 Supplements (MAJOR EFFECT) Oral B12 Supplements: Typical dose: 1000 mcg (1 mg) Absorption: ~1-2% passively absorbed (10-20 mcg from 1000 mcg dose) Effect on serum B12: Can increase by 100-300 pg/mL within 24 hours Peak effect: 4-8 hours after oral supplement Intramuscular B12 Injections: Dose: Usually 1000 mcg Effect: Massive increase in serum B12 Can reach 1000-5000 pg/mL within hours Sustained elevation for weeks Recommendation: Stop oral supplements 3-7 days before testing (ideally 7 days) Wait 1-2 weeks after injection before testing 2
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Vargas R, Martinez-Martinez N, Lizano-Barrantes C et al (2025) Advancing through the blood-brain barrier: mechanisms, challenges and drug delivery strategies: review paper
Bacteriostatic water is specifically used because it contains a small amount of benzyl alcohol, which prevents the growth of bacteria in the vial after it has been opened
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