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The same vascular growth activity raises a biologically plausible concern: accelerating angiogenesis in a tissue that already harbors occult or established malignancy could support tumor growth

Tackling Drug-Resistant Infections Globally: Final Report and Recommendations

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Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors

Also found is that transepithelial transport of macromolecules such as protein and peptide therapeutics is highly limited (Bruno et al., 2013)