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Semaglutide can reduce B12 absorption by slowing gastric transit, but not all patients develop deficiency

4 In a parallel 36-week phase 2 obesity study, once-daily oral orforglipron produced dose-dependent weight reductions reaching a mean of about 14.7% at the top dose, with gastrointestinal effects nausea, constipation, diarrhea as the dominant, mostly mild-to-moderate adverse events, concentrated during dose escalation

Such studies suggest it might help, but more research is necessary

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Rostamtabar M, Esmaeilzadeh S, Tourani M, et al

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