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Despite an initially sensitive chemotherapy, most ovarian cancers relapse with chemoresistance, which is featured by genotypic alteration and metabolic changes
Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice
Ewes in this study were managed, treated, and used by following the ethical approval from the Animal Care and Use Committee of the Faculty of Veterinary Medicine, Cairo University (Vet CU20-09-2022-481)
Metabolite profiling of reduced thiol-containing metabolites was carried out in the presence of NEM