The conditions that may also contribute to glycine depletion include obesity, hypothyroidism, diabetes, and depression
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Chen YF, Li PL, Zou AP: Oxidative stress enhances the production and actions of adenosine in the kidney
A large number of antioxidant based strategies focusing on ascorbic acid, deferoxamine, cucurmin etc has been investigated for management of the PD symptoms but without any translatable benefits 47,48