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Therefore, the thioredoxin reductases, like most other selenoproteins, play a neuroprotective role

So far, the ADVANCE trial has provided evidence that the long-term intensive use of gliclazide prevents ESKD [35], and real-time observational data [66] indicate that it even confers additional protection from renal complications compared to other SUs (glimepiride in particular) in certain populations

Individual pharmacokinetic differences may affect drug absorption and metabolism

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[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Kubota A., Kobayashi M., Sarashina S., Takeno R., Yasuda G., Narumi K., Furugen A., Takahashi-Suzuki N., Iseki K