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Glutathione regulates melanin production by inhibiting tyrosinase, the enzyme that triggers pigmentation

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Organoids offer a clinically relevant model for testing nutritional, microbial, and pharmacologic interventions, and may ultimately help tailor radiotherapy regimens that maximize efficacy while minimizing harm

Although we cannot rule out that the increased production of ROS in 3D culture conditions may not be observed under hypoxia, it should be noted that hypoxia itself induces ROS production in numerous cell types, including tumor cells [39]