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Data availability Anonymized individual participant data may be made available along with the trial protocol

118 In a double-blind, placebo-controlled trial of 60 mechanically ventilated patients at high risk of developing ventilator-associated pneumonia (VAP), NAC significantly reduced the risk of VAP versus placebo, 26.6% versus 46.6%, and shortened intensive care unit (ICU) stay (14.4 versus 17.8 days) and hospital stay (19.2 versus 24.6 days)

The fed-batch culture was performed in a 5-L bioreactor (NC-Bio, Shanghai, China) with the initial working volume of 2.5 L