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The episode gets into the fact that for some peptides in particular the GLPs/Reta there are randomized controlled trials to support their specific uses, (also true for Melanotan and GH secretagouges) but many people are taking these compounds for things other than what they were studied and approved for

Used to investigate GH-axis physiology, visceral fat remodeling, HIV-associated lipodystrophy, and selective GH stimulation in metabolic and body-composition models

It is well-established that eicosanoids produced by the COX-2 and 5-LOX pathways contribute to the progression of colon cancer

Donaldson LB, Yan F, Morgan PF, Kaczmar JM, Fernandes JK, Nguyen SA, et al