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doi: 10.1002/14651858.CD010223.pub2 65 WichmanJWintherKHBonnemaSJHegedsL

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The levels of the methyl group donor betaine are reduced and its conversion into DMG increased in COC users The activity of COMT and the efficiency of estrogen methylation depend on the availability of the methyl group donor SAM, which is obtained from the methioninehomocysteine cycle