Evidence indicates that the pancreatic islet is dynamic, plastic, and characterized by processes of trans-differentiation and de-differentiation in a high percentage of T2DM subjects
This effect was paralleled with increases in sAC activity, as measured by cAMP accumulation in the same lysates (Figure 4B)
These include type 2 diabetes and prediabetes (because GLP-1 medications affect blood sugar), thyroid conditions (because of the boxed warning about medullary thyroid carcinoma), a history of pancreatitis (because GLP-1 medications carry a small risk of pancreatitis), gastroparesis or other gastric motility disorders (because GLP-1 medications slow gastric emptying), and any history of eating disorders (because the appetite-suppressing effects of GLP-1 medications require careful management in patients with disordered eating)
Some of the side effects you reported to us included hair loss, vomiting and diarrhea, extreme exhaustion and rash at injection side
However, pharmacological and preclinical data are gathering (Table 2)