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Cardiovascular Considerations with a Combination of Metformin and a GLP-1 RA The Evaluation of Lixisenatide in the Acute Coronary Syndrome (ELIXA) trial, the first reported GLP-1 RA CVOT, demonstrated no increased CVD risk with lixisenatide

The medication does not alter blood composition in ways that would harm recipients or compromise transfusion safety

Liraglutide causes thyroid C-cell tumors at clinically relevant exposures in rodents

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