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A peer-reviewed study found that GHRP-2 reduced expression of Cd86, Nos2, and tnfa (all with statistical significance at P less than 0.01), suggesting inhibited M1 macrophage polarization

Cell Metab (2023) 35(1):3655

M.PattB

Low SAM, excessive methylation demand, impaired creatine synthesis, reduced glutathione availability and oxidative stress may place additional strain on mitochondria, potentially contributing to fatigue, variable cognitive stamina, sensory sensitivity, poor stress tolerance and slow recovery from illness

However, all is not lost in the potential for use of IGF therapies in the treatment of cancer