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Mitochondria resulting from a fission event that are unable to re-establish m (an indication of damage), fails to reintegrate to the fusing pool and is likely an early event preceding mitophagy (Twig et al

Thats the palmitoyl part, which makes it fat-soluble so it can actually penetrate

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4 The combination of unresolved biomechanical and biochemical stress promotes secondary alterations which lead to a predominant catabolic microenvironment