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These medications are contraindicated in patients with: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) For patients with standard hypothyroidism (typically autoimmune thyroiditis or post-ablation), these contraindications do not apply

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Safety monitoring revealed mild gastrointestinal side effects like nausea, but no severe adverse events or negative fetal outcomes were attributed to GLP-1 exposure

Emerging evidence suggests that GIPR antagonism could improve the tolerability of agonists by reducing nausea, according to a 2025 study 9