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The upregulation of GPX4 leads to an irisin-mediated decrease in acute kidney injury (AKI) induced by ischemia-reperfusion (I/R)

Both the GLS gene encoded enzymes and the GLS2 encoded enzymes require phosphate for activity

Bioorg Med Chem Lett 22:18221826 Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ et al (2020) Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

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