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CLINICAL BOX 15-1: CHRONIC GRANULOMATOUS DISEASE Because of the need for NADPH in phagocytic cells, by the NADPH oxidase system, any defect in enzymes in this process can result in impaired killing of infectious organisms

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More commonly, AC is used as the first capture step, the followed by one or more steps to remove remaining impurities

These immune cells must have sufficient energy to reach the infected area, then utilize NADPH as a cofactor to produce ROS, and eventually destroy pathogens and impaired tissue [143]