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To explore through an alternative strategy whether GLP-1R binding kinetics influence PM recycling and insulin secretion, we utilized the GLP-1R allosteric modulator 4-(3-( b enzyloxy)phenyl)-2-( e thylsulfinyl)-6-( t rifluoro-methyl) p yrimidine (BETP), which alters the residence time of orthosteric GLP-1R agonists 45

Can you start both GLP-1 and MHT treatments at the same time

Specific binding studies indicate that silent agonists stabilize certain receptor conformations favorable for interaction with endogenous neurotransmitters, potentially leading to more nuanced control of receptor activity [79, 80]

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