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In men with DA-resistant prolactinomas and persistent HH, the aromatase inhibitors (anastrozole and letrozole), when administered combined with high-dose CAB, resulted in a significant decrease in PRL concentration and tumor shrinkage (224, 225)

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For instance, a landmark study on a human gut-liver-kidney on chip demonstrated the accurate replication of human-specific pharmacokinetics of cisplatin, predicting its dose-dependent nephrotoxicity which is a human-relevant outcome that can be poorly predicted by rodent models (211)