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PMID: 144 MervielPJamesPBoueSLe GuillouMRinceCNachtergaeleCet al

Combined use demonstrates improved outcomes in animal research, including: Faster formation of granulation tissue and wound closure Reduced edema and inflammation Enhanced tendon-to-bone integration and ligament tensile strength Systemic protection of organs such as liver and kidney in ischemia-reperfusion models Systematic reviews of over 35 preclinical studies consistently report positive histological and functional results, with no observed toxicity

The primary outcomes were disability or death at 90 days (modified Rankin Scale, mRS3)

The adhesion strength of PTK hydrogel was measured at a cross-head speed of 50 mm min 1

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