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TGR5 activation ameliorates mitochondrial homeostasis via regulating the PKC/Drp1-HK2 signaling in diabetic retinopathy

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Introduction The first reports about a plant glutathione S-transferase enzyme (GST, EC 2.5.1.18) appeared in 1970, when it was revealed that a GST catalyzed the detoxification of the herbicide atrazine by its conjugation to the endogenous tripeptide glutathione (GSH, -L-glutamyl-L-cysteinyl-glycine) in sorghum and maize plants (Frear and Swanson, 1970

10.1007/s00394-019-01999-2 Eur J Nutr