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127 Another clinical trial with 180 participants compared a combination of vitex (40 mg), soy isoflavones (60 mg), magnolia (50 mg), Lactobacillus sporogenes (109 spores [the dormant form of this bacterium]), and vitamin D (35 mcg or 1,400 IUs) to soy isoflavones alone for 12 months and found the combination formula was more effective for reducing frequency and intensity of hot flashes, and improving sleep and psychological wellness

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CAUTION: If you are pregnant, may become pregnant, or breastfeeding, or are taking any prescription drug, consult your health care professional before using this product

Rather than acting in isolation, it operates within a complex microbial network that regulates barrier integrity, mucosal turnover, and hostmicrobe communication