There are many different types of estrogens that your body must eliminate and metabolize
The isozyme class is subsequently identified with an upper-case letter (e.g., "A" for alpha), followed by an Arabic numeral representing the class subfamily (or subunit)
Major limitations for SGLT-2i initiation include limited use in patients with a history of recurrent genito-urinary tract infections, significant renal impairment, lower limb amputation, and euglycemic DKA
Diabetes Care 25 , 13981404 (2002)
It is strongly associated with the development and progression of hepatic steatosis, increased oxidative stress, mitochondrial dysfunction, activation of pro-inflammatory and pro-fibrotic pathways, and systemic metabolic dysregulation