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We've observed institutional research protocols split daily doses above 100mg into twice-daily administration (morning and early evening) to maintain more stable plasma levels throughout the 24-hour cycle

Therefore, the review suggests that, to improve FM symptoms, physical exercise and an energy deficit are necessary, as elevated BMI levels have been directly linked to increased pain and functional status in FM patients [28]

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[3] If you have concerns about the cost or availability of prescribed treatments, discuss this openly with your GP, who may be able to suggest alternatives or provide guidance on accessing medications through appropriate NHS channels